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Interesting Articles

“Breakthrough as highly effective malaria vaccine raises hopes of controlling disease”

“Breakthrough as highly effective malaria vaccine raises hopes of controlling disease”

April 21, 2021

A vaccine against malaria has shown record efficacy in a Phase II trial, a pre-print study released on Friday by Oxford University shows, raising hopes that one of the world's most deadly diseases could be brought under control.

The vaccine, developed by Oxford and known as R21, showed up to 77% efficacy in a trial of 450 children in Burkina Faso over 12 months, the university said in a statement. It said the shot was the first to meet the World Health Organization's Malaria Vaccine Technology Roadmap goal of a malaria vaccine with at least 75% efficacy.
"These are very exciting results showing unprecedented efficacy levels from a vaccine that has been well tolerated in our trial programme," Halidou Tinto, the trial's principal investigator, said in a statement. "We look forward to the upcoming Phase III trial to demonstrate large-scale safety and efficacy data for a vaccine that is greatly needed in this region."
    The study inoculated 450 children between the ages of 5 to 17 months. They were split into three groups, and researchers reported the higher dose group were 77% less likely to get the disease, "and 71% in the lower dose adjuvant group, over 12 months of follow-up," the statement said.
      It was noted that there were "no serious adverse events related to the vaccine," the statement added.
      Researchers, together with their commercial partners the Serum Institute of India and drugmaker Novavax, are now recruiting for a Phase III trial "to assess large-scale safety and efficacy in 4,800 children, aged 5-36 months, across four African countries.
      In the future, the university and its partners hope to be able to manufacture at least 200 million doses annually, which would have a "major public health impact if licensure is achieved," the statement said.
      Malaria is a parasitic disease transmitted through the bite of female Anopheles mosquitoes. It is both preventable and treatable, yet an estimated 435,000 people die of it each year, with the majority being children younger than five.
      The African region was home to 94% of all malaria cases and deaths in 2019, according to the WHO.
        "Malaria is one of the leading causes of childhood mortality in Africa," said Charlemagne Ouédraogo, Burkina Faso's Minister of Health, said in the statement.
        "We have been supporting trials of a range of new vaccine candidates in Burkina Faso and these new data show that licensure of a very useful new malaria vaccine could well happen in the coming years. That would be an extremely important new tool for controlling malaria and saving many lives."

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        “Roselyne's journey toward healing By facing and accepting her eczema, Roselyne Kuete of France has found a way to tame its worst symptoms while exploring her gift for entrepreneurialism.”

        “Roselyne's journey toward healing By facing and accepting her eczema, Roselyne Kuete of France has found a way to tame its worst symptoms while exploring her gift for entrepreneurialism.”

        April 21, 2021

        One day in the winter of 2009, a spot on the back of Roselyne Kuete’s left forearm started itching. A few days later, two dry patches appeared. She made an appointment with a dermatologist, who told her she had eczema and prescribed a mild cortisone cream and moisturizer. The patches went away, and that was that — or so she thought.

        The itchy patches soon returned to the same place on her arm. This time, her dermatologist prescribed a slightly stronger cortisone cream. Before long, a pattern emerged: after each course of cortisone treatment, Kuete noticed her symptoms return with a vengeance.

        Meanwhile, her dry patches were expanding to other parts of her body, including her upper arms, legs, back and chest, while the intervals between flares were getting shorter and shorter.

        “At first, I’d have a flare once every two months or so,” said Kuete, “but later, they came more and more often. At its worst, my eczema would flare every day. It was terrifying because I didn’t have time to heal between flares.”

        Visible evidence

        That failure to heal showed up in the form of scarring. “The dark blotches all over my skin made me look like a giraffe,” she said.

        Kuete wanted nothing more than to hide her condition. That was easily accomplished during the colder seasons when she could wear pants or leggings with long-sleeved tops and sweaters. But the warmer months were another story.

        “I could barely summon the nerve to wear skirts, shorts or T-shirts and I was always looking for ways to cover up, even if it meant that I’d be sweaty and miserable when the temperature soared.”

        Kuete rarely spoke about her eczema, not even with her closest friends or relatives. No one knew how bad it was, not even Kuete herself. Instead of facing the serious nature of her condition and its negative impacts on her life, she remained in denial.

        “I think I buried my head in the sand to avoid confronting it,” she confessed.

        Her wake-up call came when her mother caught sight of her arms and legs. “You used to have such beautiful skin,” her mom told her. “What happened? You need to do something about it!”

        At that moment, Kuete saw herself through her mother’s eyes. She finally admitted to herself that she couldn’t continue to hide the truth — or her scars — from her loved ones or from herself. Since conventional medicine failed to help her, she decided to find ways to help herself.

        A path to self-healing

        Kuete started researching foods and natural products with the potential to ease her eczema symptoms and decidedto try some of them out. After nine months of exploration, “I started seeing modest results,” she said. “For one, my itching had become less intense. It took me nine more months to get rid of 90% of my scars.”

        A couple of years later, Kuete’s skin had changed for the better, “and so had I,” she quipped. “I had grown much more aware of my needs, my environment and the interaction between the two.

        “Now, I can recognize the signs of a flare before it happens,” she continued, “and I can take steps to prevent a full-blown episode. These days, my skin only flares about once a year, and my flares are much, much milder than they were before I set out on my journey toward healing.

        “My success in dealing with my eczema came when I accepted the need to live with my condition rather than fight it,” Kuete explained. “At that point, I let go of the past and started focusing on small, achievable goals — and I was rewarded far above my expectations.”

        A life across two cultures

        Kuete was born and raised in Cameroon, a country in Central Africa, where her parents continue to live. Nearly 20 years ago, she moved to France to pursue graduate studies in management. She earned her master’s degree and took a position with a bank in Paris.

        “I am fully integrated into the French way of life,” she said, “and I also travel to Cameroon regularly. I have one foot planted firmly on each side of the fence, allowing me to switch easily from one culture to another.”

        Kuete grew up in the bosom of a caring family that gave her the space to express herself, develop self-confidence and work hard to reach her goals. Athletic and intellectually curious, she credits her dad as the source of two of her strongest passions: tennis and wine!

        “I prefer a red wine with a woodsy, musky taste,” she said with a just a hint of a smile.

        A self-proclaimed global citizen, Kuete benefits from a support system that includes family and friends all over the world. And yet she confesses to being “old school.”

        “I’d rather see people face-to-face than engage with them on social media,” Kuete admitted. “The exception is WhatsApp, mainly because I have friends and extended family in so many countries that I couldn’t keep up with them without it.”

        An entrepreneur with heart

        Kuete’s management background, her natural taste for entrepreneurship and her empathy for those who share her condition have recently come together in an exciting new way. She’s in the process of building a business charged with helping people manage their itch, whether caused by eczema or other skin conditions.

        She’ll aim to provide coaching services to adults and children, focusing on preventive strategies, natural treatments and advice regarding potential environmental triggers. She plans to share what has worked best for her: organic, plant-based oils that she formulated to heal her own skin during and between flares.

        Her mantra? If you can manage your condition when your skin is clear, you may be able to limit or even prevent future flares. That’s at the heart of Kuete’s approach to complementary medicine — one that’s working for her and, she hopes, might work for others seeking a gentle path to healing.

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        April 21, 2021

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